Fri Sep 13 2024

25 articles - From Friday Sep 06 2024 to Friday Sep 13 2024

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Comparative Efficacy of Novel Biologics, Antitumour Necrosis Factor Agents, and Immunomodulators to Prevent Postoperative Recurrence in Crohn's Disease: A Systematic Review and Network Meta-analysis.

According to direct and network meta-analysis, in CD patients after surgical resection, novel biologics, especially vedolizumab, were quite effective in decreasing the risk of endoscopic POR, whereas anti-TNFs appeared to perform best in reducing the risk of clinical POR.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Inflamm Bowel Dis

Association Between Maternal Infections in Pregnancy and the Risk of Inflammatory Bowel Disease in the Offspring: Findings From Two Scandinavian Birth Cohorts.

In this binational birth cohort study, the risk of offspring IBD varied by infection type and timing but not with maternal antibiotic use in pregnancy.

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Mortality Trends in Inflammatory Bowel Disease by Age, Sex, and Race in the United States from 1999 to 2020.

All-cause mortality trends in IBD were stable until 2018 and rose between 2018 and 2020. Mortality rates were higher amongst the elderly and White adults. Females with CD and males with UC had higher mortality rates.

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J Crohns Colitis

Differences in the Adverse Event Burden of Corticosteroid Use in Inflammatory Bowel Disease as Reported Between Adverse Event Reporting Systems and a Patient Questionnaire.

AEs associated with IBD-related corticosteroid use were frequent. Patients reported AEs affecting quality of life, while clinicians disproportionately reported AEs based on objective diagnostic criteria.

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IL23R-specific CAR Tregs for the treatment of Crohn's disease.

Overall, our results demonstrate that IL23R-CAR Tregs represent a promising therapy for active CD.

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Novel Microbial Engraftment Trajectories following Microbiota Transplantation Therapy in Ulcerative Colitis.

SourceTracker can be used as a simple and reliable method to quantify donor microbial community engraftment and donor taxa contribution in patients with ulcerative colitis and other inflammatory conditions treated with microbiota transplant therapy.

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Prevalence, characteristics, management, and outcomes of difficult-to-treat inflammatory bowel disease.

Certain IBD phenotypes and the delay in initiating treatment in CD were risk factors for DTT. Drug persistency decreased progressively with every subsequent line of therapy.

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Liver Transpl

Long-term maternal outcomes of pregnancy after orthotopic liver transplantation in the Netherlands - a retrospective multicenter cohort study.

However, while pregnancy does not seem to impact survival after OLT, we do show that a substantial number of children will lose their mother early in life. We believe this is important for pregnancy counseling of OLT patients and their partners.

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Pancreas

Characterization of Human Pancreatic Islet Cells using a Single-Cell Western Blot Platform.

These results demonstrate that each alpha, beta, and delta cells express varying levels of peptide hormones, and a small subpopulation co-expresses double hormones in normal human islets. The scWestern platform will enable timely assessment of beta cell mass in isolated islets before clinical transplantation.

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Cost-effectiveness of operative intervention for mucinous cystic neoplasm: the role of post-operative diabetes.

Surveillance for small suspected MCNs without high-risk features is the preferred strategy from a clinical and economic standpoint. Consensus guidelines should consider the long-term implications of postoperative diabetes development following LDP.

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Increased PRIM2 expression associated with poor-prognosis in patients with pancreatic ductal adenocarcinoma.

High expression of PRIM2 associated with poor prognosis in PDAC patients, PRIM2 could be used as an independent risk indicator.

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Individualized Pain Treatment in Chronic Pancreatitis (INPAIN): An International, Multicenter, Investigator-initiated, Prospective, Cohort Study.

The INPAIN study aims to comprehensively understand pain in CP through a test panel developed for routine clinical use. This tool has the potential to personalize treatments, improve clinical practice, enhance patient care, improve quality of life, and minimize treatment side effects.

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PATIENT AND FAMILY INPUT TO DETERMINE EXPERIENCES AND RESEARCH INTERESTS IN PEDIATRIC PANCREATITIS: AN INSPPIRE-2 STUDY.

This study highlights the importance of patient and family input in caring for children with pancreatitis. The most bothersome symptoms were pain, fatigue and upset stomach. Children with pancreatitis and families would like future research to primarily focus on prevention of pancreatitis attacks, pain therapy, and complications of pancreatitis.

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Risk factors and a prediction model for pain recurrence after pancreatic stent removal in painful chronic pancreatitis.

We identified the risk factors and developed a new prediction model for pain recurrence following stent removal. This model might be useful for decision-making in pancreatic stent management, such as deciding whether to remove a pancreatic stent, continue EPS, or convert to surgery.

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Pancreatology

Performance of explainable artificial intelligence in guiding the management of patients with a pancreatic cyst.

EBM models had greater sensitivity and specificity for identifying the correct management compared with either clinical management or previous AI models. The model predictions are demonstrated to be interpretable by clinicians.

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Prognostic significance of involvement of the circumferential resection margin/surface in patients with pancreatic head cancer: A prospective evaluation of pancreatoduodenectomy specimens using the 0 and 1mmrules.

The results suggest that CRM involvement defined by the 0 mm rule is more appropriate than the 1 mm rule for predicting survival outcomes, but CS involvement defined by the 0 or 1 mm rules is not prognostically significant.

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Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer.

The gut and oral microbiome differed between patients with pancreatic cancer and healthy controls, with a notable decrease in butyrate-producing bacteria in the gut microbiome of the patients. This suggests that there may be a distinct microbial signature associated with pancreatic cancer in the Japanese population. Further studies are required to elucidate the microbiome's causal role in this cancer and help develop prognostic markers or targeted therapies.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Inflamm Bowel Dis

Refining the Understanding of Cannabis Impact on Inflammatory Bowel Disease Outcomes: Recommendations for Enhanced Research and Healthcare Practices.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Risk of Paradoxical Rheumatoid Arthritis in Inflammatory Bowel Disease Patients Exposed to Tumor Necrosis Factor Inhibitors: A Propensity-Matched Multicenter Study.

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Liver Transpl

Bulevirtide improves liver function in liver transplant candidates with advanced HDV cirrhosis and severe portal hypertension.

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CON: Patients with acute-on-chronic liver failure should not be offered MELD exception points.

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Leter to the editor: time for validating GEMA-Na in the united states for liver transplant waiting list prioritization.

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Pancreas

Mortality trends for acute pancreatitis during the COVID-19 pandemic in the US.

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Tumor immune microenvironment promotes cachexia in pancreatic cancer.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreas

From the Rare to the Extraordinary: Pancreatic Serous Cystadenocarcinoma With Hepatic and Bone Dissemination: A Letter to the Editor.

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